Basic mechanisms of neuronal hyperexcitability

Proceedings of the Fourth Symposium of the Centre de recherche en sciences neurologiques of the Universite ... 17 and 18, 1982 (Neurology and neurobiology) by Universite de Montreal

Publisher: Liss

Written in English
Cover of: Basic mechanisms of neuronal hyperexcitability | Universite de Montreal
Published: Pages: 495 Downloads: 999
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  • Action potentials (Electrophysiology),
  • Elliott, K. A. C,
  • Neural circuitry,
  • Excitation (Physiology),
  • Neurons,
  • Congresses,
  • Physiology
The Physical Object
FormatUnknown Binding
Number of Pages495
ID Numbers
Open LibraryOL8245607M
ISBN 100845127012
ISBN 109780845127018

Invited Faculty Presentations — Jeffrey L. Noebels, M.D., Ph.D. Noebels J, Avoli M, Rogawski MA, Vezzani A, Delgado-Escueta AV. [Organizers and chief editors] In: 5 th International Workshops, 5 th Jasper's Basic Mechanisms of the Epilepsies (BME) Workshops, Yosemite National Park, Calif. (March , ).; Noebels J, Delgado-Escueta A, Rossignol E. Book Section III: Genes and Network. Epileptogenesis is the gradual process by which a normal brain develops epilepsy. Epilepsy is a chronic condition in which seizures occur. These changes to the brain occasionally cause neurons to fire in a hyper-synchronous manner, known as a seizure. 2 Latent period. 3 Pathophysiology. Neural reorganization. Glutamate receptor activation.   The book discusses these challenges in the clinic and brings them back to the laboratory bench (and in some cases back to the bedside). This book fills a gap in the literature on developing epilepsy by bridging current clinical knowledge with basic and translational research in the developing brain relevant for developmental epilepsy. We use electrophysiological, molecular, and anatomical techniques to evaluate neuronal circuitry in normal and in epileptic brains. Huguenard, John, PhD. We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system.

  Recent experimental evidence on the clustering of glutamate and GABA transporters on astrocytic processes surrounding synaptic terminals pose the question of the functional relevance of the astrocytes in the regulation of neural activity. In this perspective, we introduce a new computational model that embeds recent findings on neuron–astrocyte coupling at the mesoscopic scale intra- and Cited by: 2. Conclusion: The findings elucidate the mechanisms by which downregulation of the expression and reduction of the activity of KCNQ2/3/5 channels in diabetic rat dorsal root ganglion neurons contribute to neuronal hyperexcitability, which results in hyperalgesia. These data provide intriguing evidence that activation of KCNQ2/3/5 channels might be. neuronal hyperexcitability by a novel neuron-glia mass model Aurélie Garnier, Alexandre Vidal, Habib Benali To cite this version: Aurélie Garnier, Alexandre Vidal, Habib Benali. A theoretical study on the role of astrocytic activity in neuronal hyperexcitability by a . hyperexcitability: A term referring to exaggerated bronchial constriction of unknown pathogenesis, which most commonly occurs in asthmatics in response to nonspecific provocation (inhalation of various bronchoconstrictors), but also to physical challenges—e.g., exercise, dry or cold air, hypertonic or hypotonic aerosols.

  Fundamentals of neuronal excitability relevant to seizures and epilepsy. Neurobiological research has progressed swiftly during the last decade, providing detailed information on the molecular, pharmacological, and functional characteristics of voltage- and ligand-gated membrane signaling mechanisms regulating neuronal network by: Click on the sign to list the book chapters and other publications by year. Then click on the link for details of that publication. Goldman A. Basic mechanisms of SUDEP. In: Chapman D, Panelli R, Hanna J, Jeffs T, editors. Novartis Foundation, editor. Sodium channels and neuronal hyperexcitability. New York: John Wiley & Sons. For more than 35 years, his research has addressed the functions and mechanisms of adaptive neuronal responses to axonal or tissue injury in diverse species (the sea slug Aplysia, squid, moth larvae, rats, and mice), often from comparative and evolutionary perspectives.   Special Issue: Basic Mechanisms of Pediatric Epilepsy Special Issue: Basic Mechanisms of Pediatric Epilepsy Cepeda, Carlos; Wu, Jie Developmental Psychologist Jean Piaget once declared that a child is not an adult in miniature. By extension, we can say that the brain of a child is not just an adult brain in miniature.

Basic mechanisms of neuronal hyperexcitability by Universite de Montreal Download PDF EPUB FB2

Get this from a library. Basic mechanisms of neuronal hyperexcitability: proceedings of the Fourth Symposium of the Centre de recherche en sciences neurologiques of the Université de Montréal, held in Montréal, May 17 [Herbert H Jasper; Nico M Van Gelder; Université de Montréal.

Centre de recherche en sciences neurologiques. Basic Anatomy of Cortex. The human cerebral cortex consists of 3 to 6 layers of neurons. The phylogenetically oldest part of the cortex (archipallium) has 3 distinct neuronal layers, and is exemplified by the hippocampus, which is found in the medial temporal majority of the cortex (neocortex or neopallium) has 6 distinct cell layers and covers most of the surface of the cerebral Cited by:   InH.H.

Jasper, A.A. Ward, and A. Pope and the Public Health Service Advisory Committee on the Epilepsies of the National Institutes of Health published the first edition of Basic Mechanisms of the Epilepsies.

The book was developed following a workshop held in Colorado Springs and an open symposium. Since then, basic and clinical researchers in epilepsy have gathered.

Sodium Channels and Neuronal Hyperexcitability by Gregory R. Bock,available at Book Depository with free delivery worldwide. Sodium Channels and Neuronal Hyperexcitability 1st Edition how they work and the mechanisms that restrict their expression to particular cell types.

this book represents compulsory reading for basic and medical scientists with an interest in the function of sodium channels. Brings together both the basic biology and biophysics with detailed consideration of the medical applications in chronic pain and epilepsy.

Includes coverage of channelopathies, sodium channel gene expression, the modulation of sodium channels, and molecular mechanisms of gating and drug block of sodium channels.

Neuromyotonia (NMT) is a form of peripheral nerve hyperexcitability that causes spontaneous muscular activity resulting from repetitive motor unit action potentials of peripheral origin. The prevalence of NMT is unknown but – cases have been reported so far.

1 Signs and symptoms. Peripheral nerve hyperexcitability. 7 External lty: Neurology, neuromuscular medicine. Basic Mechanisms of Neuronal Hyperexcitability Herbert H. Dealer. New York, NY, US. Price. USD. Buy now. About the item. First Edition.

8vo. NEAR FINE in Near Fine dust jacket. The book itself shows the former ownership signature of Dr. Mark Rayport, eminent biologist, on the paste-down, otherwise is FIne/As New being completely. Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types.

This book explains how these channels are modulated in various pathological states to enable the development of therapeutic strategies based on sodium channel restoration. The authors present the most current. In: Jasper HH, Van Gelder NM (eds) Basic mechanisms of neuronal hyperexcitability.

Alan R Liss, New York, pp – Google Scholar Levitt P, Noebels JL () Mutant mouse tottering: selective increase of locus coeruleus axons in a defined single-locus by: 5.

Contribution to Book Migraine and Epilepsy—Shared Mechanisms within the Family of Episodic Disorders supporting the view that neuronal hyperexcitability is an initiating event. Epidemiological studies demonstrate that epilepsy and migraine are comorbid conditions. This is likely due to shared genetic or environmental factors (such as head.

Basic Mechanisms of Neuronal Hyperexcitability: Neurology and Neurobiology, vol 2 By Brian Meldrum Topics: Book ReviewAuthor: Brian Meldrum. Get this from a library. Sodium channels and neuronal hyperexcitability. [Gregory Bock; Jamie Goode;] -- "Recent progress has led to a better understanding of the molecular structure of sodium channels, how they work and the mechanisms that restrict their expression to particular cell types.

This book. Kelly Knupp, Amy R. Brooks-Kayal, in Swaiman's Pediatric Neurology (Sixth Edition), Clinical Features. Benign familial neonatal seizures are an autosomal-dominant epilepsy presenting with seizures in the first or second week of life, most commonly starting on day of life 2 or 3, resolving within weeks to months.

Most seizures have stopped at 4 to 5 months of life. In this chapter, we aim to review the current trends in the molecular and cellular mechanisms in charge of neurological damage following mild TBI (mTBI) with a particular focus on neural hyperexcitability as well as discussing positive treatment findings that aim to mitigate the neuronal damage following : Nicola Maggio, Vardit Rubovitch, Barry J.

Hoffer, Bruce A. Citron, Nigel H. Greig, Chaim G. Pick. Self-propagating waves of cerebral neuronal firing, known as spreading depolarisations, are believed to be at the roots of migraine attacks. We propose that the start of spreading depolarisations corresponds to a critical transition that occurs when dynamic brain networks approach a tipping point.

We show that this hypothesis is consistent with current pathogenetic insights and observed dynamics. isolated spikes resulting from synchronous neuronal activations. NIS typically mim-ics local field potentials (LFP) recordings obtained during pre-ictal phases of epilepsy as shown in [29] and may thus be used as a predictor for the insurgence of neuronal hyperexcitability.

A novel computational model based on the neural mass approach that Cited by: 2. Mechanisms of eosinophil major basic protein-induced hyperexcitability of vagal pulmonary chemosensitive neurons Article (PDF Available) in AJP Lung.

Mechanisms of Neuronal Hyperexcitability Caused by Partial Inhibition of Na+-K+-ATPases in the Rat CA1 Hippocampal Region Article in Journal of Neurophysiology 88(6) January with 9.

H.H. Jasper, A.A. Ward, A. Pope and H.H. Merritt, chair of the Public Health Service Advisory Committee on the Epilepsies, National Institutes of Health, published the first volume on Basic Mechanisms of the Epilepsies (BME) in Their ultimate goal was to search for a "better understanding of the epilepsies and seek more rational methods of their prevention and treatment."4/5(1).

Basic Mechanisms Underlying Seizures Epileptogenesis is the sequence of events that turns a norma\൬ neuronal network into a hyperexcitable network.

\⠀匀氀椀搀攀 ㈀尩\爀ꀀ 刀攀挀漀最渀椀稀椀渀最 琀栀攀 搀椀猀琀椀渀挀琀椀漀渀 戀攀琀眀攀攀渀 猀攀椀稀甀爀攀猀 愀渀搀 攀瀀椀氀攀瀀猀. Howard A. Miller, David A. Majors, and Wilbur W. Oak. Basic Mechanisms of Neuronal Hyperexcitability. Herbert H. Jasper and Nico N. van Gelder (eds.). The Primary Care of Seizure Disorders.

We introduce a computational model of CA3 region of hippocampus, consisting of a network of an astrocyte and a pyramidal cell with a feedback inhibited interneuron, to investigate the effects of a) potassium clearance and buffering by glial cells, and Author: Vasily Grigorovsky, Berj L Bardakjian.

The basic physiology of the EEG and its rhythms has been the topic of intense research since its due to neuronal hyperexcitability in this region. Another theory based on its reactivity, similar to Mechanisms.

Basic mechanisms of cerebral rhythmic activities. Electroencephalogr Clin Neurophysiol ; 76(6)– Sensory Ecology:Review and Perspectives (NATO Advanced Study Institutes Series.) by M. Ali, National Research Council Canada, North Altantic Treaty Organization, Universite de Montreal and a great selection of related books, art and collectibles available now at How to Cite.

Noebels, J. () Sodium Channel Gene Expression and Epilepsy, in Sodium Channels and Neuronal Hyperexcitability: Novartis Foundation Symposium is needed to balance the neuronal adaptations and maintain normal brain function.

Removal of alcohol from the body induces a rebound stimulatory effect, resulting in hyperexcitability of the nervous system (i.e., withdrawal syndrome). SOURCE: Adapted from Metten and Crabbe 0 + Drug-free Withdrawal Acute Sedation Chronic Tolerance Time LastFile Size: KB.

Basic Mechanisms of Neuronal Injury from Seizures and Status Epilepticus Intrinsic Mechanisms Contributing to Hyperexcitability of Human Epileptogenic Cortex This online reference work provides the breadth and depth of content Elsevier is known for and also offers a great deal more when it comes to flexibility, accessibility, and most.

Epilepsy is one of the most common neurological disorders affecting about 1% of population. Although the precise mechanism of its pathophysiological changes in the brain is unknown, epilepsy has been recognized as a disorder of brain excitability characterized by recurrent unprovoked seizures that result from the abnormal, excessive, and synchronous activity of clusters of nerve cells in Cited by:   A dietary supplement dampens the brain hyperexcitability seen in seizures or epilepsy These results, seen in animal models, represent a potentially novel therapeutic target for.

Lang F (ed): Mechanisms and Significance of Cell Volume Regulation. Contrib Nephrol. Basel, Karger,volpp – Volume Changes in Neurons: Hyperexcitability and Neuronal Death Herminia Pasantes-Morales, Karina Tuz Department of Biophysics, Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, Mexico City.Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and journal has focused on research concerning basic mechanisms underlying neurological disorders.

US National Institutes of Health (NIH) voluntary posting ("Public Access") policy.Le Réseau français des instituts d’études avancées (RFIEA) a été créé, par décret en marssous la forme d’une fondation de coopération scientifique reconnue d’utilité publique.

Dans un contexte de profonde évolution de la recherche, la France a décidé de se doter d’instituts d’études avancées (IEA) — institutions qui ont fait leurs preuves dans le panorama.